Liposomal supplement manufacturer
Phospholipid hydration, high-shear mixing, and per-batch encapsulation checks at HBM's Tampa Bay liquid facility.
HBM is a liposomal supplement manufacturer running the full process in-house at its Tampa Bay liquid facility. Phospholipid hydration is handled on the same line as the main mix, sharing 2,500L of jacketed mixing capacity across three 500L vessels and one 1,000L vessel. Each vessel has a high-speed roto-stator and sweeping blades, which is the shear profile liposomal formulation requires. Encapsulation efficiency is verified per batch. The fill spec, the carrier system, and the targeted particle size are locked at pilot batch and held through commercial production. MOQ is 3,000 units or 150L. HBM holds 8 certifications including FDA Registration, NSF, and USDA Organic.
Liposomal is the system buyers ask about most when they want better bioavailability for vitamin C, glutathione, or NAD+ precursors. The chemistry is straightforward. The process discipline is where most contract runs go wrong. This page covers what HBM actually does on a liposomal batch. Equipment, process steps, MOQ, fill range, and the spec lock at pilot.
How liposomal delivery works
A liposome is a phospholipid bilayer that encapsulates the active. The bilayer is typically phosphatidylcholine sourced from sunflower or soy lecithin. The structure protects the active from gastric pH and, for some molecules, changes the absorption profile. Liposomal delivery bioavailability depends on three variables. Encapsulation efficiency. Particle size. Stability across shelf life. Each one is set during formulation and verified at pilot batch. Encapsulation efficiency is the percent of active that ends up inside the liposome versus free in solution. HBM verifies this per batch. Particle size matters because smaller liposomes (50-200nm) behave differently from larger ones (>500nm). The target size is fixed at pilot and held through commercial production.
Equipment used for liposomal batches
HBM’s liquid mixing room runs three 500L jacketed vessels and one 1,000L jacketed vessel. Total capacity is 2,500L. Each vessel has a high-speed roto-stator and sweeping blades. The roto-stator delivers the shear needed to form the bilayer. The sweeping blades prevent hot or cold spots against the vessel wall. The jacket controls temperature during hydration and cool-down. This is the same equipment used for emulsion and suspension work. The difference is the process recipe, not the hardware.
Process steps on a liposomal batch
Phospholipid hydration runs first. The lecithin is dispersed in the aqueous phase under controlled shear. Temperature and pH are held within the formulation’s tolerance. The active is introduced next. The shear profile is held through the encapsulation window. A sample is pulled and tested for encapsulation efficiency before the batch moves forward. Final pH adjustment, preservation, and flavor system go in last. Then the batch is cooled and held for fill.
Fill range and SKU sizes
Six semi-automatic and fully automatic fillers cover a 3ml to 64oz fill range. Typical liposomal SKUs land in the 30ml to 240ml window. The semi-automatic lines run 10,000 units per day per line across 5 lines. The fully automatic line runs 30,000 units per day in the 0.5oz to 4oz range, which covers most shot-format and tincture-format liposomal SKUs. Glass, PET, and amber options are all available. Headspace and closure choice get reviewed at packaging review (step 6 of the 10-step framework).
MOQ and lead times
MOQ for liposomal is 3,000 units or 150L. The 150L floor reflects mixing efficiency. Below 150L the 500L vessels cannot mix cleanly enough for liposomal work. Lead times follow the standard liquid program. Bench samples run 2-4 weeks. Pilot batch runs 2-4 weeks. Commercial production runs 4-8 weeks from approved pilot. A formal preliminary estimate comes back within 24 hours of an R&D intake.
Frequently asked questions
What is a liposomal supplement manufacturer?
A liposomal supplement manufacturer formulates and produces supplements where the active is encapsulated in a phospholipid bilayer. HBM runs liposomal batches in-house at its Tampa Bay liquid facility. The work uses jacketed mixing vessels with high-speed roto-stators. Encapsulation efficiency is verified per batch. HBM holds 8 certifications including FDA Registration, NSF, and USDA Organic.
What is the MOQ for a liposomal run at HBM?
HBM's liposomal MOQ is 3,000 units or 150L, whichever the buyer prefers. The 150L floor reflects mixing efficiency. Below that volume, the 500L vessels cannot deliver clean liposomal hydration. Most first runs land between 3,000 and 10,000 units in 30ml to 240ml fill sizes.
How does HBM verify liposomal delivery bioavailability?
Bioavailability claims are structure/function territory and sit with the brand, not HBM. What HBM verifies is encapsulation efficiency. That is the percent of active inside the liposome versus free in solution. HBM pulls a sample per batch and tests it. The target particle size is also locked at pilot batch and held through commercial production.
What fill sizes does HBM offer for liposomal SKUs?
Total fill range across HBM's six fillers is 3ml to 64oz. Typical liposomal SKUs land in the 30ml to 240ml window. The fully automatic line covers 0.5oz to 4oz at 30,000 units per day. The five semi-automatic lines cover the wider range at 10,000 units per day each.
What is the lead time for a liposomal product at HBM?
A formal preliminary estimate comes back within 24 hours of intake. Bench samples then run 2-4 weeks. Pilot batch runs 2-4 weeks. Commercial production runs 4-8 weeks from an approved pilot. HBM holds these timelines across all liquid systems, including liposomal.
Talk to R&D.
Send the active, target dose, and fill size. HBM returns a formal preliminary estimate within 24 hours.
Start R&D intake